The prophylactic supplementation of freshly calved multiparous cows with oral calcium supplements (bolus, drink, drench, paste) has increased in popularity in recent years. Oral calcium supplements are generally only effective for 12 hours, yet the high-risk period for hypocalcaemia in freshly calved multiparous cows is 48 hours post-partum. Therefore, a second application 12 hours post-partum is suggested by manufacturers, yet due to labour shortages on dairy farms, it is very common for the second application to not be carried out. The objectives of this study were to ascertain if a the administration of a single dose of the sustained release bolus (Cow Start Complete, Anchor Life Science, Co. Cork, Ireland) given to the cow at calving, could offer the combined benefits of elevated calcium status over the first 48 hours post-partum from a labour efficient single dose given at calving and also to evaluate if this enhanced calcium status could have a positive effect on daily rumination time and milk production yields in the first three months of lactation. The two groups consisted of an un-supplemented control (CON) group and a Cow Start Complete (CSC) group in which cows were given a single bolus dose at the point of calving. The CON group experienced a clinical milk fever (Blood Ca <1.5mmol/L) incidence rate of 13.3% compared to 0% for the CSC group. Cows given the CSC treatment had significantly (P<0.0001) higher total blood calcium levels (2.14 mmol/L) from the point of calving (0h) to 4 days post-partum (96h) compared to CON (1.98mmol/L), with significant increases at 12h (P<0.01), 24h (P<0.001) and 36h (P<0.01) post-partum. Rumination time for CSC cows (471mins/day) was significantly (P<0.05) higher during the first 14 days post-partum when compared to CON (434mins/day) group. Milk production was also significantly (P<0.01) higher for CSC cows (+1.8kg/day) than in CON cows during the first 90 days of lactation. These findings demonstrate that the convenience of giving a single dose of CSC at calving, can be combined with desired outcomes in a range of key benefits in freshly calved multiparous cows.
Published in | Animal and Veterinary Sciences (Volume 12, Issue 6) |
DOI | 10.11648/j.avs.20241206.12 |
Page(s) | 154-160 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sustained Release Calcium, Sub-clinical Hypocalcemia, Transition Cow, Milk Yield, Rumination Status
[1] | J. P. Goff, ‘The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows’, The Veterinary Journal, vol. 176, no. 1, pp. 50–57, 2008, |
[2] | J. K. Drackley. “ADSA foundation scholar award: Biology of dairy cows during the transition period: The final frontier?” J. Dairy Sci. 82: 2259–2273, 1999, |
[3] | T. A. Reinhardt, J. D. Lippolis, B. J. McCluskey, J. P. Goff, and R. L. Horst. “Prevalence of subclinical hypocalcemia in dairy herds”. Vet. J. 188: 122–124, 2011, |
[4] | L. S. Caixeta, P. A. Ospina, M. B. Capel, and D. V. Nydam. “The association of subclinical hypocalcemia, negative energy balance and disease with bodyweight change during the first 30 days post-partum in dairy cows milked with automatic milking systems”. Vet. J. 204: 150–156, 2015, |
[5] | P. L. Venjakob, S. Borchardt, and W. Heuwieser. “Hypocalcemia— Cow-level prevalence and preventive strategies in German dairy herds”. J. Dairy Sci. 100: 9258–9266, 2017, |
[6] | D. C. Blood, O. M. Radostits, and J. A. Henderson. “Veterinary Medicine: A Textbook of the Diseases of Cattle, Sheep, Pigs and Horses”. 6th ed., 1983, Bailliere Tindall, ed. London. |
[7] | G. K. Oetzel. “Parturient paresis and hypocalcemia in ruminant livestock”. Vet. Clin. North Am. Food Anim. Pract. 4: 351–364, 1988, |
[8] | N. Martinez, C. A. Risco, F. S. Lima, R. S. Bisinotto, L. F. Greco, E. S. Ribeiro, F. Maunsell, K. Galvao, and J. E. P. Santos. “Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease”. J. Dairy Sci. 95: 7158–7172, 2012, |
[9] | L. S. Caixeta, P. A. Ospina, M. B. Capel, and D. V. Nydam. “Association between subclinical hypocalcemia in the first 3 days of lactation and reproductive performance of dairy cows”. Theriogenology 94: 1–7, 2017, |
[10] | J. A. A. McArt, and R. C. Neves. “Association of transient, persistent, or delayed subclinical hypocalcemia with early lactation disease, removal, and milk yield in Holstein cows”. J. Dairy Sci. 103: 690–701, 2020, |
[11] | C. R. Seely, B. M. Leno, A. L. Kerwin, T. R. Overton, and J. A. A. McArt. “Association of subclinical hypocalcemia dynamics with dry matter intake, milk yield, and blood minerals during the periparturient period”. J. Dairy Sci. 104: 4692–4702, 2021, |
[12] | R. C. Neves, B. M. Leno, T. Stokol, T. R. Overton, and J. A. A. McArt. “Risk factors associated with postpartum hypocalcaemia in dairy cows”. J. Dairy Sci. 100: 3796-3804, 2017, |
[13] | R. C. Neves, M. Leno, K. D. Bach, and J. A. A. McArt. “Epidemiology of subclinical hypocalcemia in early-lactation Holstein dairy cows: The temporal associations of plasma calcium concentration in the first 4 days in milk with disease and milk production”. J. Dairy Sci. 101: 9321–9331, 2018a, |
[14] | G. R. Oetzel. “Oral calcium supplementation in peripartum dairy cows”. Vet. Clin. North Am. Food Anim. Pract. 29: 447–455, 2013, |
[15] | A. Valldacabres, J. A. A. Pires, and N. Silva-del-Rio. “Effect of prophylactic oral calcium supplementation on postpartum mineral status and markers of energy balance of multiparous Jersey cows,” J. Dairy Sci. vol. 101: 4460–4472, 2018, |
[16] | B. M. Leno, R. C. Neves, I. M. Louge, M. D. Curler, M. J. Thomas, T. R. Overton, and J. A. A. McArt. “Differential effects of a single dose of oral calcium based on postpartum plasma calcium concentration in Holstein cows,” J. Dairy Sci.vol. 101: 3285–3302, 2018, |
[17] | J. Lawlor, A. Fahey, E. Neville, A. Stack, and F. Mulligan, “On-farm Safety and Efficacy Trial of Cow Start Calcium Bolus,” Anim. Vet. Sci., vol. 7, no. 6, pp. 121–126, 2019, |
[18] | J. Lawlor, Fahey, A., Neville, E., Stack, A., and Mulligan, F. “Effect of Cow Start Calcium Bolus on Metabolic Status and Milk Production in Early Lactation,” Anim Vet Sci., vol. 8, no. 6, pp. 124-132, 2020, |
[19] | J. Lawlor, R. Reardon, C. O’Sé, E. Neville, and A. Stack. “Effect of Cow Start Bolus Supplementation on Early Lactation Health and Performance Indicators in a Group of Older, At-Risk Dairy Cows” Anim Vet Sci., vol. 9, no. 5, pp. 134-140, 2021, |
[20] | J. Lawlor “Functionality, Effectiveness and Delivery of Oral Calcium Boluses in Elevating Blood Calcium of Freshly Calved Cows” a Review of Commercially Available Products. Anchor Life Science Ltd., 2024. |
[21] | C. R. Curtis, H. N. Erb, C. J. Sniffen, R. D. Smith, P. A. Powers, M. C. Smith, M. E. White, R. B. Hillman, and E. J. Pearson. “Association of parturient hypocalcemia with eight periparturient disorders in Holstein cows”. J. Am. Vet. Med. Assoc. 183: 559–561, 1983. |
[22] | H. N. Erb, R. D. Smith, P. A. Oltenacu, C. L. Guard, R. B. Hillman, P. A. Powers, M. C. Smith, and M. E. White. “Path model of reproductive disorders and performance, milk fever, mastitis, milk yield, and culling in Holstein cows”. J. Dairy Sci. 68: 3337–3349, 1985, |
[23] | Melendez, P., G. A. Donovan, C. A. Risco, and J. P. Goff. “Plasma mineral and energy metabolite concentrations in dairy cows fed an anionic prepartum diet that did or did not have retained fetal membranes after parturition”. Am. J. Vet. Res. 65: 1071–1076, 2004, |
[24] | Kimura, K., J. P. Goff, M. E. Kehrli Jr., and T. A. Reinhardt. “Decreased neutrophil function as a cause of retained placenta in dairy cattle”. J. Dairy Sci. 85: 544–550, 2002. |
[25] | S. S. Hansen, P. Nørgaard, C. Pedersen, R. J. Jorgensen, L. S. B. Mellua and J. D. Enemark. “The Effect of Subclinical Hypocalcaemia induced by Na2EDTA on the Feed Intake and Chewing Activity of Dairy Cows”. Veterinary Research Communications 27: 193-205, 2003, |
[26] | R. C. Daniel. “Motility of the rumen and abomasum during hypocalcaemia”. Can. J. Comp. Med. 47: 276–280, 1983. |
[27] | J. Lawlor and A. Fahey. “Effect of Cow Start supplementation on cow health, fertility, and milk production performance of high production Holstein cows”. Internal White Paper, 2021. |
[28] | J. A. A. McArt, and G. R. Oetzel, “A stochastic estimate of the economic impact of oral calcium supplementation in post parturient cows,” Journal of Dairy Science vol. 98: 7408–7418, 2015, |
[29] | G. R. Oetzel, and B. E. Miller. 2012. “Effect of oral calcium bolus supplementation on early-lactation health and milk yield in commercial dairy herds,” J. Dairy Sci. vol. 95: 7051–7065, 2012, |
[30] | A. Valldecabres, R. Branco-Lopes, C. Bernal-Córdoba, and N. Silva-del-Río. “Production and reproduction responses for dairy cattle supplemented with oral calcium bolus after calving: Systemic review and meta-analysis”. JDS Communications, 2022. |
APA Style
Lawlor, J., Neville, E., Fahey, A. (2024). Can Supplementation with the Cow Start Complete Bolus Result in Elevated Blood Calcium Status in a Group of At-Risk Dairy Cows During the First Four Days of Lactation. Animal and Veterinary Sciences, 12(6), 154-160. https://doi.org/10.11648/j.avs.20241206.12
ACS Style
Lawlor, J.; Neville, E.; Fahey, A. Can Supplementation with the Cow Start Complete Bolus Result in Elevated Blood Calcium Status in a Group of At-Risk Dairy Cows During the First Four Days of Lactation. Anim. Vet. Sci. 2024, 12(6), 154-160. doi: 10.11648/j.avs.20241206.12
AMA Style
Lawlor J, Neville E, Fahey A. Can Supplementation with the Cow Start Complete Bolus Result in Elevated Blood Calcium Status in a Group of At-Risk Dairy Cows During the First Four Days of Lactation. Anim Vet Sci. 2024;12(6):154-160. doi: 10.11648/j.avs.20241206.12
@article{10.11648/j.avs.20241206.12, author = {John Lawlor and Enda Neville and Alan Fahey}, title = {Can Supplementation with the Cow Start Complete Bolus Result in Elevated Blood Calcium Status in a Group of At-Risk Dairy Cows During the First Four Days of Lactation }, journal = {Animal and Veterinary Sciences}, volume = {12}, number = {6}, pages = {154-160}, doi = {10.11648/j.avs.20241206.12}, url = {https://doi.org/10.11648/j.avs.20241206.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20241206.12}, abstract = {The prophylactic supplementation of freshly calved multiparous cows with oral calcium supplements (bolus, drink, drench, paste) has increased in popularity in recent years. Oral calcium supplements are generally only effective for 12 hours, yet the high-risk period for hypocalcaemia in freshly calved multiparous cows is 48 hours post-partum. Therefore, a second application 12 hours post-partum is suggested by manufacturers, yet due to labour shortages on dairy farms, it is very common for the second application to not be carried out. The objectives of this study were to ascertain if a the administration of a single dose of the sustained release bolus (Cow Start Complete, Anchor Life Science, Co. Cork, Ireland) given to the cow at calving, could offer the combined benefits of elevated calcium status over the first 48 hours post-partum from a labour efficient single dose given at calving and also to evaluate if this enhanced calcium status could have a positive effect on daily rumination time and milk production yields in the first three months of lactation. The two groups consisted of an un-supplemented control (CON) group and a Cow Start Complete (CSC) group in which cows were given a single bolus dose at the point of calving. The CON group experienced a clinical milk fever (Blood Ca <1.5mmol/L) incidence rate of 13.3% compared to 0% for the CSC group. Cows given the CSC treatment had significantly (P<0.0001) higher total blood calcium levels (2.14 mmol/L) from the point of calving (0h) to 4 days post-partum (96h) compared to CON (1.98mmol/L), with significant increases at 12h (P<0.01), 24h (P<0.001) and 36h (P<0.01) post-partum. Rumination time for CSC cows (471mins/day) was significantly (P<0.05) higher during the first 14 days post-partum when compared to CON (434mins/day) group. Milk production was also significantly (P<0.01) higher for CSC cows (+1.8kg/day) than in CON cows during the first 90 days of lactation. These findings demonstrate that the convenience of giving a single dose of CSC at calving, can be combined with desired outcomes in a range of key benefits in freshly calved multiparous cows. }, year = {2024} }
TY - JOUR T1 - Can Supplementation with the Cow Start Complete Bolus Result in Elevated Blood Calcium Status in a Group of At-Risk Dairy Cows During the First Four Days of Lactation AU - John Lawlor AU - Enda Neville AU - Alan Fahey Y1 - 2024/11/26 PY - 2024 N1 - https://doi.org/10.11648/j.avs.20241206.12 DO - 10.11648/j.avs.20241206.12 T2 - Animal and Veterinary Sciences JF - Animal and Veterinary Sciences JO - Animal and Veterinary Sciences SP - 154 EP - 160 PB - Science Publishing Group SN - 2328-5850 UR - https://doi.org/10.11648/j.avs.20241206.12 AB - The prophylactic supplementation of freshly calved multiparous cows with oral calcium supplements (bolus, drink, drench, paste) has increased in popularity in recent years. Oral calcium supplements are generally only effective for 12 hours, yet the high-risk period for hypocalcaemia in freshly calved multiparous cows is 48 hours post-partum. Therefore, a second application 12 hours post-partum is suggested by manufacturers, yet due to labour shortages on dairy farms, it is very common for the second application to not be carried out. The objectives of this study were to ascertain if a the administration of a single dose of the sustained release bolus (Cow Start Complete, Anchor Life Science, Co. Cork, Ireland) given to the cow at calving, could offer the combined benefits of elevated calcium status over the first 48 hours post-partum from a labour efficient single dose given at calving and also to evaluate if this enhanced calcium status could have a positive effect on daily rumination time and milk production yields in the first three months of lactation. The two groups consisted of an un-supplemented control (CON) group and a Cow Start Complete (CSC) group in which cows were given a single bolus dose at the point of calving. The CON group experienced a clinical milk fever (Blood Ca <1.5mmol/L) incidence rate of 13.3% compared to 0% for the CSC group. Cows given the CSC treatment had significantly (P<0.0001) higher total blood calcium levels (2.14 mmol/L) from the point of calving (0h) to 4 days post-partum (96h) compared to CON (1.98mmol/L), with significant increases at 12h (P<0.01), 24h (P<0.001) and 36h (P<0.01) post-partum. Rumination time for CSC cows (471mins/day) was significantly (P<0.05) higher during the first 14 days post-partum when compared to CON (434mins/day) group. Milk production was also significantly (P<0.01) higher for CSC cows (+1.8kg/day) than in CON cows during the first 90 days of lactation. These findings demonstrate that the convenience of giving a single dose of CSC at calving, can be combined with desired outcomes in a range of key benefits in freshly calved multiparous cows. VL - 12 IS - 6 ER -