| Peer-Reviewed

Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey

Received: 26 June 2015     Accepted: 10 August 2015     Published: 6 September 2015
Views:       Downloads:
Abstract

Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.

Published in Animal and Veterinary Sciences (Volume 3, Issue 5)
DOI 10.11648/j.avs.20150305.14
Page(s) 141-143
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Lead, Histological Alterations, Liver

References
[1] Hurst, H. E., Martin, M. D. 2004. Toxicology in Yagiela, J. A. ; Dowd, F. I. Neidle, E. A. Pharmacology and Therapeutic for Dentistry. 5th Edn., Mosby, USA,. pp. 829-48.
[2] Silbergeld, E. K. 2005. Learners and learning in the twenty-first century: what do we know about students’ attitudes towards and experiences of information and communication technologies that will help us design courses? Stud High Educ, 30(3): 257-74.
[3] Riaz, F., Khan, U. A., Ayub, M., Shaukat, S. 2011. Protective role of ginger on lead induced derangement in plasma testosterone and luteinizing hormone levels of male Sprague Dawley rats. J Ayub Med Coll Abbottabad, 23(4).
[4] Tian, L., Lawrence, D. A. 1995. Lead inhibits nitric oxide production in vitro by murine splenic macrophages. ToxicolApplPharmacol, 132(1): 156-63.
[5] Kosnett, M. J. 2004. Heavy Metal Intoxication and Chelators. In Katzung, B. G. Basic and Clinical Pharmacology. Mc Graw-Hill, New York. pp. 970-81.
[6] Meyer, P. A., Brown, M. J., Falk, H. 2008. Global approach to reducing lead exposure and poisoning. Mutat Res - Rev Mut Res, 659(1): 166-75.
[7] Goyer, R. A., Clarkson, T. W. 1996. Toxic effects of metals. Casarett&Doull’s Toxicology The Basic Science of Poisons, Fifth Edition, Klaassen, CD [Ed] McGraw-Hill Health Professions Division, ISBN, 71054766: pp. 811-67.
[8] Loghman-Adham, M. 1997. Renal effects of environmental and occupational lead exposure. Environmental Health Perspectives, 105(9): 923-8.
[9] Gidlow, D. A. 2004. Lead Toxicity. Depth Review Occupational Medicine, 54: 76-81.
[10] Plumlee, K. H. 2004. Metals and Minerals in Clinical Veterinary Toxicology, 1st Edn. Mosby, U.S.A. pp. 193-230.
[11] Durgut, R., Koc, A., Gonenci, R., Bal, R., Celik, S., Guzel, M., et al. 2008. Effects of high dose lead toxication on liver, kidneys, heart, brain and blood in rabbits: an experimental study. Journal of Applied Biological Sciences, 2(2): 11-8.
[12] US-EPA. 1986. Air quality criteria document for lead (Pb), Vol. 4. Washington DC: US Environmental Protection Agency. PP. 264-7.
[13] Piasek, M., Kostial, K., Bunarević, A. 1989. The effect of lead exposure on pathohistological changes in the liver and kidney in relation to age in rats. Arhivzahigijenuradaitoksikologiju, 40(1): 15-21.
[14] Kojima, M., Sekikawa, K., Nemoto, K., Degawa, M. 2005. Tumor necrosis factor-α-independent downregulation of hepatic cholesterol 7α-hydroxylase gene in mice treated with lead nitrate. Toxicological Sciences, 87(2): 537-42.
[15] Calabrese, E. J., Baldwin, L. A. 1992. Lead-induced cell proliferation and organ-specific tumorigenicity. Drug Metabolism Reviews, 24(3): 409-16.
[16] Suzuki, T., Morimura, S., Diccianni, M. B., Yamada, R., Hochi, S.-i., Hirabayashi, M., et al. 1996. Activation of glutathione transferase P gene by lead requires glutathione transferase P enhancer I. Journal of Biological Chemistry, 271(3): 1626-32.
[17] Gajawat, S., Sancheti, G., Goyal, P. 2005. Vitamin; C against Concomitant Exposure to Heavy Metal and Radiation: A Study on Variations in Hepatic Cellular Counts. Asian Journal of Experimental Sciences, 19(2): 53-8.
Cite This Article
  • APA Style

    Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. (2015). Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Animal and Veterinary Sciences, 3(5), 141-143. https://doi.org/10.11648/j.avs.20150305.14

    Copy | Download

    ACS Style

    Khatere Khosravian Dehkordi; Soraya khosravian Dehkordi; Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim. Vet. Sci. 2015, 3(5), 141-143. doi: 10.11648/j.avs.20150305.14

    Copy | Download

    AMA Style

    Khatere Khosravian Dehkordi, Soraya khosravian Dehkordi, Rahmat Allah Fatahian Dehkordi. Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey. Anim Vet Sci. 2015;3(5):141-143. doi: 10.11648/j.avs.20150305.14

    Copy | Download

  • @article{10.11648/j.avs.20150305.14,
      author = {Khatere Khosravian Dehkordi and Soraya khosravian Dehkordi and Rahmat Allah Fatahian Dehkordi},
      title = {Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey},
      journal = {Animal and Veterinary Sciences},
      volume = {3},
      number = {5},
      pages = {141-143},
      doi = {10.11648/j.avs.20150305.14},
      url = {https://doi.org/10.11648/j.avs.20150305.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20150305.14},
      abstract = {Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Histopathological Study of the Rat Liver Exposed with Lead Acetate as a Microscopic Survey
    AU  - Khatere Khosravian Dehkordi
    AU  - Soraya khosravian Dehkordi
    AU  - Rahmat Allah Fatahian Dehkordi
    Y1  - 2015/09/06
    PY  - 2015
    N1  - https://doi.org/10.11648/j.avs.20150305.14
    DO  - 10.11648/j.avs.20150305.14
    T2  - Animal and Veterinary Sciences
    JF  - Animal and Veterinary Sciences
    JO  - Animal and Veterinary Sciences
    SP  - 141
    EP  - 143
    PB  - Science Publishing Group
    SN  - 2328-5850
    UR  - https://doi.org/10.11648/j.avs.20150305.14
    AB  - Lead is one of the environmental pollutants that can effect on the life of living animates in several ways; it has a long half-life and is collected in the soft tissue and conduct to adverse effects in tissues. The present study was performed to investigate the histological effects caused by lead in the rat liver. The study was conducted on 20 rat, the animals were divided into 2 equal groups. The first group received distilled water and considered as a control group. The second groups were orally administered lead acetate 8.5 mg/l of body weight for 20 weeks. The rats were anesthetized, the liver were removed for histological studies. Histological changes which observed in the liver were vacuolation, fatty degeneration, congestion within central veins, hemorrhage and infiltration of inflammatory cells. In this study, harmful toxic effects observed in liver of rats.
    VL  - 3
    IS  - 5
    ER  - 

    Copy | Download

Author Information
  • Department of Animal Physiology, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran

  • Department of Basic Sciences, Azad University of Shahrekord, Shahrekord, Iran

  • Department of Basic Sciences, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran

  • Sections